The complexity and size of drug candidates has grown in recent years as scientists pursue novel targets once considered undruggable. As a result, discovery teams are increasingly faced with the challenge of compounds demonstrating poor aqueous solubility. The solubility of a drug molecule is vital for its bioavailability. If a drug is not sufficiently soluble,
Over the past century, small molecule drugs have represented the dominant modality in drug research, enabling medical breakthroughs that have saved countless lives. A small molecule achieves therapeutic effects by binding to a target protein and blocking or inhibiting the protein’s functions, or changing the protein’s shape in a way that impacts downstream cellular interactions.