LiveDesign's cloud-based informatics and discovery environment has expanded to support scientists and teams in the discovery of novel biologics.

BY Cindy Gerson

Over the past century, small molecule drugs have represented the dominant modality in drug research, enabling medical breakthroughs that have saved countless lives. A small molecule achieves therapeutic effects by binding to a target protein and blocking or inhibiting the protein’s functions, or changing the protein’s shape in a way that impacts downstream cellular interactions.

BY Lingle Wang, Ph.D.

The complexity and size of drug candidates has grown in recent years as scientists pursue novel targets once considered undruggable. As a result, discovery teams are increasingly faced with the challenge of compounds demonstrating poor aqueous solubility. The solubility of a drug molecule is vital for its bioavailability. If a drug is not sufficiently soluble,

BY Richard Hong, Ph.D. & Ana Rojas, Ph.D.